Effects of clopidogrel on “aspirin specific” pathways of platelet inhibition

Alex R. Hobson, Zeshan Qureshi, Phil Banks, & Nick P. Curzen

The most widely accepted methods of assessing response to clopidogrel involve isolated ADP-induced platelet aggregation. Whilst poor response determined by these assays correlates with adverse clinical events, the number of “poor responders” is far higher than the number of events attributed to treatment failure. Clopidogrel may have effects that cannot be assessed using isolated ADP-induced aggregation. We have investigated the effect of clopidogrel on Arachidonic Acid (AA) induced platelet activation – an “aspirin specific” pathway using a novel near patient assay.

Dr Zeshan Qureshi

About the author

Children's doctor. London. Mental health. Global health. Medical education. TEDx talk (doctor well being).

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